Association of genetic variation of the adiponectin gene with body fat distribution and carotid atherosclerosis in Japanese obese subjects
Association of genetic variation of the adiponectin gene with body fat distribution and carotid atherosclerosis in Japanese obese subjects
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DOI：
10.5551/jat.14.19
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发表时间：
2007-02-01
影响因子：
4.4
通讯作者：
Yamagishi, Masakazu
中科院分区：
文献类型：
--
作者：
Katsuda, Yuko;Asano, Akimichi;Yamagishi, Masakazu
目的：本研究的目的是探讨脂联素基因SNP 45对日本肥胖者体脂分布和颈动脉粥样硬化的影响。方法：共调查了64名肥胖者。采用聚合酶链反应-限制性片段长度多态性方法检测SNP 45基因型。内脏脂肪面积（VFA）和皮下脂肪面积（SFA）使用计算机断层扫描测量。采用B超颈动脉斑块评分（PS）评价动脉粥样硬化的进展。携带SNP 45的G等位基因的男性，（172.8 ± 50.8 vs. 147.1 ± 58.7，p = 0.005），SFA较低（209.9+/-101.8 vs. 273.4+/-142.2，p = 0.007），VFA/SFA（V/S）比值较高（1.00+/-0.46 vs. 0. 60 +/-0.26，p < 0.001）和更高的PS（9.5+/-3.7 vs. 6. 8 +/-4.2，p = 0.012）。多因素分析显示SNP 45是男性V/S比值和PS的独立决定因素。在亚组分析中，PS仅在45 G等位基因携带者中与V/S比值相关。结论：G等位基因可能是日本肥胖人群中代谢综合征和动脉粥样硬化发生的危险因素。
Aim: The aim of this study was to investigate the effect of SNP45 of the adiponectin gene on body fat distribution and carotid atherosclerosis in Japanese obese subjects.Methods: A total of 64 obese subjects were investigated. Genotypes of SNP45 were assayed by polypmerase chain reaction-restriction fragment length polymorphism. Visceral fat area (VFA) and subcutaneous fat area (SFA) were measured using computed tomography. The progression of atherosclerosis was evaluated by plaque score (PS) of carotid artery using B-mode ultrasonography.Results: Men carrying the G allele of SNP45 showed higher VIA (172.8+/-50.8 vs. 147.1+/-58.7, p = 0.005), lower SFA (209.9+/-101.8 vs. 273.4+/-142.2, p = 0.007), higher VFA/SFA (V/S) ratio (1.00+/-0.46 vs. 0.60+/-0.26, p < 0.001) and higher PS (9.5+/-3.7 vs. 6.8+/-4.2, p = 0.012) than those with TT genotype. Multivariate analysis showed that SNP45 was an independent determinant of V/S ratio and PS in men. In subgroup analysis, PS tended to be associated with V/S ratio only in the carrier of 45G allele.Conclusion: These results suggest that the G allele could be a risk factor of metabolic syndrome and the development of atherosclerosis in Japanese obese subjects.