Is schizophrenia a lifetime disorder of brain plasticity, growth and aging?
Is schizophrenia a lifetime disorder of brain plasticity, growth and aging?
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DOI：
10.1016/s0920-9964(96)00079-5
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发表时间：
1997-02-07
影响因子：
4.5
通讯作者：
DeLisi, LE
中科院分区：
文献类型：
--
作者：
DeLisi, LE
慢性精神分裂症的特征是正常大脑皮层结构的改变，不对称性减少和脑室扩大。争论仍在继续，这些异常是否发生在发展的早期，或代表一个积极的渐进过程中继续发病后的精神病。在本手稿中，我们提出了一个持续的异常终生脑过程。有人提出，精神分裂症的神经病理学基础在于决定大脑生长速率的缺陷基因的周期性激活。这一过程会在产前和整个幼儿期引起微妙的皮质发育不良，在青春期修剪神经元时再次激活，并在整个成年期的大脑逐渐老化过程中再次激活。因此，提出了精神分裂症进行性活跃大脑过程的案例。
Chronic schizophrenia is characterized by change in the normal brain cortical structure, asymmetric reduction, and ventricular enlargement. The debate continues as to whether these anomalies occur early in development or represent an active progressive process continuing after the onset of psychosis. The case is made in the present manuscript for a continuing aberrant lifetime brain process. It is proposed that the underlying basis for the neuropathology of schizophrenia resides in the periodic activation of a defective gene or genes that determine the rate of cerebral growth. This process causes subtle cortical maldevelopment prenatally and through early childhood, is activated again during adolescent pruning of neurons, and again during the gradual aging process in the brain throughout adulthood. The case for a progressive active brain process in schizophrenia is thus presented.