Should the definition of preeclampsia include a rise in diastolic blood pressure of >/=15 mm Hg to a level <90 mm Hg in association with proteinuria?
Should the definition of preeclampsia include a rise in diastolic blood pressure of >/=15 mm Hg to a level <90 mm Hg in association with proteinuria?
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DOI：
10.1067/mob.2000.108865
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发表时间：
2000-10
影响因子：
9.8
通讯作者：
R. Levine;M. Ewell;J. Hauth;L. Curet;P. Catalano;C. Morris;G. Choudhary;B. Sibai
中科院分区：
文献类型：
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作者：
R. Levine;M. Ewell;J. Hauth;L. Curet;P. Catalano;C. Morris;G. Choudhary;B. Sibai
目的本研究旨在比较有蛋白尿的正常血压妇女与无蛋白尿的舒张压升高>/=15 mm Hg妇女的基线特征和妊娠结局。研究设计：我们研究了4302名来自钙预防先兆子痫试验的健康初产妇，她们在妊娠≥ 20周时分娩。我们选择的研究组为血压正常的女性，这些女性在舒张压相对于基线升高>/=15 mm Hg的7天内发生蛋白尿，两次间隔4 - 168小时。基线血压是妊娠22周前2次门诊访视时测量的平均值。用于比较的其他血压正常的妇女是那些没有发生妊娠期高血压或舒张压升高>/=15 mm Hg与蛋白尿相关的妇女。结果除了体重增加（P <0.05）与蛋白尿相关外，与其他血压正常的女性相比，无显著性差异。虽然他们有更大的体重增加率（P /=15 mm Hg），但与蛋白尿相关，似乎是良性的，不是一个有用的临床结构。
OBJECTIVE This study was undertaken to compare baseline characteristics and pregnancy outcomes between normotensive women who did and those who did not have a rise in diastolic blood pressure of >/=15 mm Hg in association with proteinuria. STUDY DESIGN We studied 4302 healthy nulliparous women from the Calcium for Preeclampsia Prevention trial who were delivered at >/=20 weeks' gestation. We selected as the study group normotensive women who developed proteinuria within 7 days of a rise in diastolic blood pressure of >/=15 mm Hg with respect to baseline on 2 occasions 4 to 168 hours apart. Baseline blood pressure was the mean of measurements at 2 clinic visits before 22 weeks' gestation. Other normotensive women used for comparison were those who did not develop gestational hypertension or a rise in diastolic blood pressure of >/=15 mm Hg in association with proteinuria. RESULTS Except for greater weight (P /=15 mm Hg in association with proteinuria did not differ significantly from those of the other normotensive women. Although they had a greater rate of weight gain (P /=15 mm Hg in association with proteinuria appears to be benign and is not a useful clinical construct.