A biological characteristic extrapolation of compound toxicity for different developmental stage species with toxicokinetic-toxicodynamic model
A biological characteristic extrapolation of compound toxicity for different developmental stage species with toxicokinetic-toxicodynamic model
复制标题
利用毒代动力学-毒效动力学模型外推不同发育阶段物种的化合物毒性的生物学特性
DOI：
10.1016/j.ecoenv.2020.111043
复制
发表时间：
2020
影响因子：
6.8
通讯作者：
Zhu Lin
中科院分区：
文献类型：
--
作者：
Gao Yongfei;Xie Zhicheng;Feng Mingfeng;Feng Jianfeng;Zhu Lin
Intraspecific difference in toxicity brings uncertainty to ecological risk assessment (ERA) and water quality criteria (WQC) of chemicals. Here, we compared intraspecies sensitivity to toxicants forMesocyclops leuckartiof which toxicity data was obtained from published literatures,and zebrafishDanio rerioof which toxicity data was done in this study). Due to the internal concentration of chemicals not measured, simplified toxicokinetic-toxicodynamic (TK-TD) models were used, and we investigated whether TK-TD parameters estimated by Bayesian method might represent the differences in sensitivity between life-stages of 2 species. The results demonstrated that the difference in TK-TD parameters (background mortalitym0, no effect concentrationNEC, the killing rateks, and the dominant ratekd) could represent the toxicity difference between life-stages of individual species. The TK-TD model could predict toxicity in individual species (Cyprinus carpioL.,Enchytraeuscrypticus,Folsomia candida,Hyalella Azteca) exposed to different chemical concentrations and successfully extrapolate toxicity between different life stages ofMesocyclops leuckartiandDanio rerioby scaling several TK-TD parameters. The modified TK-TD model on the extrapolation toxicity of chemicals between life stages for species could be useful for the ERA and for deriving and revising WQC for chemicals.
