Conjugated linoleic acid isomers: Differences in metabolism and biological effects
Conjugated linoleic acid isomers: Differences in metabolism and biological effects
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DOI：
10.1002/biof.13
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发表时间：
2009-01-01
期刊：
影响因子：
6
通讯作者：
Puy Portillo, Maria
中科院分区：
文献类型：
--
作者：
Churruca, Itziar;Fernandez-Quintela, Alfredo;Puy Portillo, Maria
术语共轭亚油酸（CLA）是指亚油酸位置异构体和几何异构体的混合物，其特征在于具有共轭双键，不像亚油酸那样被亚甲基分开。共轭亚油酸异构体作为脂质部分的次要成分出现，主要存在于牛和羊的肉类和乳制品中。最丰富的异构体是顺式-9，反式-11，占食物中总CLA的80%。这些异构体通过不同的代谢途径在体内代谢，但在两种主要异构体之间观察到可能产生生理后果的重要差异。由于其双键的位置，反式-10，顺式-12异构体比顺式-9，反式-11异构体更有效地氧化。CLA的抗癌作用引起了人们的兴趣，但关于CLA的生物学作用和性质的具体科学文献越来越多。CLA的许多生物学效应是由于研究最多的异构体顺式-9，反式-11和反式-10，顺式-12的单独作用。这些异构体协同作用也可能诱发和/或增强某些效应。虽然顺式-9，11电子异构体主要负责抗癌作用，但反式-10，12电子异构体减少体脂肪，并且它被认为是影响血脂的最有效的异构体。就胰岛素功能而言，这两种异构体似乎是人类胰岛素抵抗的原因。最后，关于免疫系统，目前尚不清楚CLA的单个异构体是否可以类似或不同地起作用。(C)2009年国际生物化学与分子生物学联合会第35卷，第1期，2009年1月/2月，第105-111页。电子邮件：mariapuy. ehu.es
The term conjugated linoleic acid (CLA) refers to a mixture of linoleic acid positional and geometric isomers, characterized by having conjugated double bonds, not separated by a methylene group as in linoleic acid. CLA isomers appear as a minor component of the lipid fraction, found mainly in meat and dairy products from cows and sheep. The most abundant isomer is cis-9,trans-11, which represents up to 80% of total CLA in food. These isomers are metabolized in the body through different metabolic pathways, but important differences, that can have physiological consequences, are observed between the two main isomers. The trans-10,cis-12 isomer is more efficiently oxidized than the cis-9,trans-11 isomer, due to the position of its double bounds. Interest in CLA arose in its anticarcinogenic action but there is an increasing amount of specific scientific literature concerning the biological effects and properties of CLA. Numerous biological effects of CLA are due to the separate action of the most studied isomers, cis-9,trans-11 and trans-10, Cis-12. It is also likely that some effects are induced and/or enhanced by these isomers acting synergistically. Although the cis-9,trons-11 isomer is mainly responsible for the anticarcinogenic effect, the trans-10,cis-12 isomer reduces body fat and it is referred as the most effective isomer affecting blood lipids. As far as insulin function is concerned, both isomers seem to be responsible for insulin resistance in humans. Finally, with regard to the immune system it is not clear whether individual isomers of CLA could act similarly or differently. (C) 2009 International Union of Biochemistry and Molecular Biology, Inc. Volume 35, Number 1, January/February 2009, Pages 105-111. E-mail: mariapuy.portillo@ehu.es