Cardiac lipotoxicity: molecular pathways and therapeutic implications.
Cardiac lipotoxicity: molecular pathways and therapeutic implications.
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DOI：
10.1007/s11897-013-0133-0
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发表时间：
2013-06
影响因子：
--
通讯作者：
Schulze, P Christian
中科院分区：
文献类型：
--
作者：
Drosatos, Konstantinos;Schulze, P Christian
Diabetes and obesity are both associated with lipotoxic cardiomyopathy exclusive of coronary artery disease and hypertension. Lipotoxicities have become a public health concern and are responsible for a significant portion of clinical cardiac disease. These abnormalities may be the result of a toxic metabolic shift to more fatty acid and less glucose oxidation with concomitant accumulation of toxic lipids. Lipids can directly alter cellular structures and activate downstream pathways leading to toxicity. Recent data have implicated fatty acids and fatty acyl coenzyme A, diacylglycerol and ceramide in cellular lipotoxicity, which may be caused by apoptosis, defective insulin signaling, endoplasmic reticulum stress, activation of protein kinase C, MAPK activation or modulation of PPARs.
