Iron-phosphine, -phosphite, -arsine, and -carbene catalysts for the coupling of primary and secondary 2 alkyl halides with aryl Grignard reagents
Iron-phosphine, -phosphite, -arsine, and -carbene catalysts for the coupling of primary and secondary 2 alkyl halides with aryl Grignard reagents
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DOI：
10.1021/jo052250
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发表时间：
2006-02-03
影响因子：
3.6
通讯作者：
Hird, M
中科院分区：
文献类型：
--
作者：
Bedford, RB;Betham, M;Hird, M
[图解]在含有β-氢的卤代烷与芳基格氏试剂的偶联反应中，已筛选出由氯化铁和多种单齿和双齿膦及精氨酸原位生成的简单催化剂。其中最好的催化剂表现出极好的活性，单齿、三烷基和三芳基亚磷酸酯配体原位形成的催化剂也是如此。无论是预制的还是原位制备的N-杂环卡宾基预催化剂也表现出了优异的性能。
[graphics]Simple catalysts formed in situ from iron chloride and a wide range of monodentate and bidentate phosphines and arsines have been screened in the coupling of alkyl halides bearing beta-hydrogens with aryl Grignard reagents. The best of these show excellent activity, as do catalysts formed in situ with monodentate trialkyl and triaryl phosphite ligands. N-heterocyclic carbene-based precatalysts, either preformed or made in situ, also show excellent performance.