Tuning the nitric oxide release from CPO-27 MOFs.
Tuning the nitric oxide release from CPO-27 MOFs.
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DOI：
10.1039/c5ra24023a
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发表时间：
2016-02-13
期刊：
影响因子：
3.9
通讯作者：
Morris RE
中科院分区：
文献类型：
--
作者：
Cattaneo D;Warrender SJ;Duncan MJ;Kelsall CJ;Doherty MK;Whitfield PD;Megson IL;Morris RE
CPO-27 MOF中一氧化氮的释放和由此产生的冠状动脉舒张反应是通过Ni在MOF框架中的同构取代来调节的。记录了ni掺杂的CPO-27 （Mg）和CPO-27 （Zn）的一氧化氮（NO）储存和释放量，并在猪冠状动脉舒张试验中评估了释放的NO的生物学效应。结果表明，与母体材料相比，掺杂策略导致NO的储存和递送水平增加，并且可以通过这种方法调整NO的剂量和生物反应，以适应特定应用的要求。
Nitric oxide release from CPO-27 MOFs and the resulting coronary artery relaxation response are tuned by isomorphous substitution of Ni into the MOF framework. Nitric oxide (NO) storage and release measurements have been recorded for Ni-doped CPO-27 (Mg) and CPO-27 (Zn), and the biological effect of the released NO was assessed in porcine coronary artery relaxation tests. The results indicate that the doping strategy leads to increased levels of NO storage and delivery compared to the parent materials and that the NO dosage and biological response can be tuned via this approach to suit the requirements of particular applications.