Polybutylcyanoacrylate nanoparticles as a carrier for mitomycin C in rabbits bearing VX2-liver tumor
Polybutylcyanoacrylate nanoparticles as a carrier for mitomycin C in rabbits bearing VX2-liver tumor
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DOI：
10.1016/j.yrtph.2006.07.008
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发表时间：
2006-12-01
影响因子：
3.4
通讯作者：
Zeng Xv-xin
中科院分区：
文献类型：
--
作者：
Yang Xi-xiao;Chen Jan-hai;Zeng Xv-xin
聚氰基丙烯酸正丁酯纳米粒（PBCA-NP）的制备是通过将单体添加到含有葡聚糖70的水相中，并负载丝裂霉素C（MMC-PBCA-NP），一种高效的抗癌药物。当注射到小鼠体内时，MMC-PBCA-NP在肝脏中的积累比游离MMC多。相比之下，MMC-PBCA-NP在心脏和肾脏中的积累少于游离MMC。但当MMC-PBCA-NP和MMC用于移植VX 2细胞的兔时，两种药物对肿瘤细胞的抗增殖作用相似。组织学分析表明，MMC治疗组中观察到心肌细丝的组织被破坏和空泡化，而MMC-PBCA-NP治疗似乎没有损害宿主的心脏。在MMC处理组中观察到肾小管上皮细胞的水肿变性，而在对照组中没有观察到，而MMC-PBCA-NP处理似乎没有损害宿主的肾脏。(c)2006年爱思唯尔公司All rights reserved.
Polybutylcyanoacrylate nanoparticles (PBCA-NP) were prepared by addition of the monomer to an aqueous phase containing dextran 70 and loaded with mitomycin C (MMC-PBCA-NP), a highly effective anticancer drug. When injected into mice, MMC-PBCA-NP accumulated more in the liver than did free MMC. In contrast, MMC-PBCA-NP accumulated less in the heart and kidney than did free MMC. However, when MMC-PBCA-NP and MMC were administered to rabbits bearing VX2 cells implanted into the liver, the anti-proliferative effects on the tumor cells of both drugs were similar. Histological analyses indicated that organization of myocardial filaments was disrupted and vacuolization was observed in the MMC treated group, whereas MMC-PBCA-NP treatment did not appear to damage the host's heart. Hydropic degeneration of renal tubular epithelia was observed in the MMC treated group and not in the control group, whereas MMC-PBCA-NP treatment did not appear to damage the host's kidney. (c) 2006 Elsevier Inc. All rights reserved.