Free-energy landscape of enzyme catalysis
Free-energy landscape of enzyme catalysis
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DOI：
10.1021/bi800049z
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发表时间：
2008-03-18
期刊：
影响因子：
2.9
通讯作者：
Hammes-Schiffer, Sharon
中科院分区：
文献类型：
--
作者：
Benkovic, Stephen J.;Hammes, Gordon G.;Hammes-Schiffer, Sharon
发展的概念，酶的机制应被视为“催化网络”与多个构象发生串行和并行的机制。这些耦合合奏的构象需要一个多维的标准自由能表面是非常“崎岖”，包含多个最小值和过渡态。实验和理论证据支持这一概念。
The concept is developed that enzyme mechanisms should be viewed as "catalytic networks" with multiple conformations that occur serially and in parallel in the mechanism. These coupled ensembles of conformations require a multi-dimensional standard free-energy surface that is very "rugged", containing multiple minima and transition states. Experimental and theoretical evidence is presented to support this concept.