Yin-Yang of costimulation: crucial controls of immune tolerance and function.
Yin-Yang of costimulation: crucial controls of immune tolerance and function.
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DOI：
10.1111/j.1600-065x.2009.00769.x
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发表时间：
2009-05
影响因子：
8.7
通讯作者：
Dong C
中科院分区：
文献类型：
--
作者：
Nurieva RI;Liu X;Dong C
除了来自T细胞受体复合物的信号外，多年来人们已经认识到“第二”信号，尤其是来自CD28的信号，在T细胞激活中也很重要。近年来，人们发现了许多CD28家族的新成员以及与CD28配体CD80和CD86具有结构同源性的分子。有趣的是，这些蛋白中的一些可以抑制T细胞的激活并调节T细胞耐受的诱导。因此，积极和消极的共刺激是硬币的两面，以微调T细胞受体信号，以确定T细胞受体接合的结果-耐受性与功能。
In addition to signals from the T cell receptor complex, it has been recognized for many years that a “second” signal, most notably from CD28, is also important in T cell activation. In the recent years, many new members of CD28 family as well as the molecules that are share structural homology to CD28 ligands CD80 and CD86 have been discovered. Interestingly, some of these proteins function to dampen T cell activation and regulate the induction of T cell tolerance. Therefore, positive and negative costimulation are the two sides of the coin to fine tune T cell receptor signaling to determine the outcome of T cell receptor engagement- tolerance vs. function.