Randomized investigation of antimicrobials for the prevention of preterm birth
Randomized investigation of antimicrobials for the prevention of preterm birth
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DOI：
10.1016/s0002-9378(96)70395-2
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发表时间：
1996-01-01
影响因子：
9.8
通讯作者：
Leveno, KJ
中科院分区：
文献类型：
--
作者：
Cox, SM;Bohman, VR;Leveno, KJ
目的：隐匿性羊水感染已成为许多迄今无法解释的早产的可能原因。我们试图确定是否抗菌治疗是有效的，在防止早产deliver.Study设计：一个双盲，安慰剂对照，随机试验进行研究的疗效氨苄西林-舒巴坦和阿莫西林-克拉维酸在24和34周之间的妊娠早产住院的妇女。在这项调查没有宫缩抑制剂或类固醇used.Results：39名妇女早产接受抗菌治疗和39名接受安慰剂。进入研究时，抗菌剂组和安慰剂组的平均胎龄分别为29.8 ± 0.4周（SEM）和30.6 ± 0.3周（无显著性）。同样，分娩时的平均胎龄分别为34.2 +/- 0.7和34.1 +/- 0.6周（不显著）。早产母亲接受抗菌药物治疗后，其他妊娠结局指标值（例如出生体重、新生儿发病率和产前死亡）并未显着改善。结论：我们发现早产妇女接受抗菌药物治疗对预防早产无效。
OBJECTIVE: Occult amniotic fluid infection has emerged as a possible cause of many heretofore unexplained preterm births. We sought to determine whether antimicrobial therapy is effective in preventing preterm delivery.STUDY DESIGN: A double-blind, placebo-controlled, randomized trial was conducted to study the efficacy of ampicillin-sulbactam and amoxicillin-clavulanic acid in women hospitalized for preterm labor between 24 and 34 weeks' gestation. During this investigation no tocolytics or steroids were used.RESULTS: Thirty-nine women with preterm labor received antimicrobial therapy and 39 received placebos. The mean gestational ages at study entry were 29.8 +/- 0.4 weeks (SEM) and 30.6 +/- 0.3 weeks in the antimicrobial and placebo groups, respectively (not significant). Similarly, the mean gestational ages at delivery were 34.2 +/- 0.7 and 34.1 +/- 0.6 weeks, respectively (not significant). Other index values of pregnancy outcome, for example, birth weight, neonatal morbidity, and prenatal death, were not significantly improved by antimicrobial therapy given to the mother in preterm labor.CONCLUSION: We find that antimicrobial therapy given to women in preterm labor is ineffective in the prevention of preterm birth.