The effect of taurine depletion on the contractile properties and fatigue in fast-twitch skeletal muscle of the mouse
The effect of taurine depletion on the contractile properties and fatigue in fast-twitch skeletal muscle of the mouse
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DOI：
10.1007/s00726-006-0291-4
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发表时间：
2006-10-01
期刊：
影响因子：
3.5
通讯作者：
Bakker, A. J.
中科院分区：
文献类型：
--
作者：
Hamilton, E. J.;Berg, H. M.;Bakker, A. J.
牛磺酸增加骨骼肌的力量产生，并且牛磺酸水平可能在运动期间下降。研究了胍基乙磺酸（GES）处理牛磺酸缺失的趾长伸肌（EDL）的收缩特性和疲劳性。GES处理使肌肉牛磺酸水平降低至对照组的< 40%。在GES处理的EDL肌肉中，峰值抽搐力水平是对照的23%（p < 0.05），但最大比力不受影响。检查了力-频率关系，并且在50至100 Hz的刺激频率下，与对照相比，GES处理的肌肉产生的力显著更小（p < 0.05）。GES处理的EDL肌肉表现出比对照显著更慢的疲劳速率（p < 0.05）。在皮肤纤维中，20 mM GES对力的产生有一个小但显著的影响，表明GES可能有一些轻微的牛磺酸样作用。在这项研究中，牛磺酸水平的下降降低了力量输出，并增加了EDL骨骼肌的耐力。
Taurine increases force production in skeletal muscle, and taurine levels may fall during exercise. The contractile properties and fatigability of extensor digitorum longus (EDL) muscles depleted of taurine by guanodinoethane sulfonate (GES) treatment were investigated. GES treatment decreased muscle taurine levels to < 40% of controls. Peak twitch force levels were 23% of controls in GES treated EDL muscles (p < 0.05), but maximal specific force was unaffected. The force-frequency relationship was examined and significantly less force was produced by the GES treated muscles compared to controls at stimulation frequencies from 50 to 100 Hz (p < 0.05). GES treated EDL muscles exhibited significantly slower rates of fatigue than controls (p < 0.05). In skinned fibres, 20 mM GES had a small but significant effect on force production, indicating that GES may have some minor taurine-like effects. In this study, a fall in taurine levels decreased force output, and increased the endurance of EDL skeletal muscles.