Cyclin G2 Inhibits the Warburg Effect and Tumour Progression by Suppressing LDHA Phosphorylation in Glioma
Cyclin G2 Inhibits the Warburg Effect and Tumour Progression by Suppressing LDHA Phosphorylation in Glioma
复制标题
Cyclin G2 通过抑制胶质瘤中的 LDHA 磷酸化来抑制 Warburg 效应和肿瘤进展
DOI：
10.7150/ijbs.30297
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发表时间：
2019-01-01
影响因子：
9.2
通讯作者：
Luo, Yang
中科院分区：
文献类型：
--
作者：
Li, Sen;Gao, Jinlan;Luo, Yang
Cyclin G2 已被确定为多种癌症的肿瘤抑制因子。然而，其在肿瘤中的调节作用和潜在机制仍不清楚。在这项研究中，我们证明细胞周期蛋白 G2 在神经胶质瘤中表达水平较低，这是该疾病的不良预后因素。我们还发现，cyclin G2可以抑制细胞增殖，启动细胞凋亡并减少有氧糖酵解，表明cyclin G2在胶质瘤中发挥抑癌作用。从机制上讲，细胞周期蛋白 G2 可以通过直接相互作用负向调节关键糖酵解酶乳酸脱氢酶 A 的酪氨酸 10 磷酸化。总而言之，这些结果表明细胞周期蛋白 G2 通过与 LDHA 相互作用抑制糖酵解和肿瘤进展，从而在神经胶质瘤中发挥肿瘤抑制因子的作用。
Cyclin G2 has been identified as a tumour suppressor in several cancers. However, its regulatory roles and underlying mechanisms in tumours are still unknown. In this study, we demonstrated that cyclin G2 was expressed at low levels in glioma, which was as a poor prognostic factor for this disease. We also found that, cyclin G2 could suppress cell proliferation, initiate cell apoptosis and reduce aerobic glycolysis, suggesting that cyclin G2 plays a tumour suppressive role in glioma. Mechanistically, cyclin G2 could negatively regulate tyrosine-10 phosphorylation of a critical glycolytic enzyme, lactate dehydrogenase A, through direct interaction. Taken together, these results indicate that cyclin G2 acts as a tumour suppressor in glioma by repressing glycolysis and tumour progression through its interaction with LDHA.