Thymic dendritic cells traffic to thymi of allogeneic recipients and prolong graft survival
Thymic dendritic cells traffic to thymi of allogeneic recipients and prolong graft survival
复制标题
DOI：
10.1172/jci200212142
复制
发表时间：
2002-03-01
影响因子：
15.9
通讯作者：
Theofilopoulos, AN
中科院分区：
文献类型：
--
作者：
Duncan, SR;Capetanakis, NG;Theofilopoulos, AN
我们已经证明，从供体小鼠分离的小鼠胸腺树突状细胞(DC)在静脉注射后能够归巢到完全同种异体受体的胸腺，在那里它们诱导T细胞缺失，并延长供体-品系呼吸道和皮肤移植物的存活时间。相反，输注的脾树突状细胞向胸腺的迁移较差，并且不影响移植物的存活。这些发现表明，优先归巢可能是介导免疫功能的DC亚群之间的一个重要机制差异，并阐明了一种新的方法学，可能有助于诱导对同种异体移植物或其他疾病相关抗原的特异性免疫无反应性。
We have demonstrated that murine thymic dendritic cells (DCs) isolated from donor mice have the capability to home to thymi of fully allogeneic recipients after intravenous injections, where they induce T cell deletions and prolong donor-strain airway and skin graft survival. In contrast, infused splenic DCs immigrated poorly to thymi, and did not affect graft survival. These findings suggest that preferential homing may be an important mechanistic difference among subpopulations of DCs that mediate immune functions and illustrate a novel methodology that could have utility for induction of specific immunologic nonreactivity to allografts, or other disease-associated antigens.