Biological implications of clonal hematopoiesis
Biological implications of clonal hematopoiesis
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DOI：
10.1016/j.exphem.2019.08.004
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发表时间：
2019-09-01
影响因子：
2.6
通讯作者：
Shlush, Liran, I
中科院分区：
文献类型：
--
作者：
Luis, Tiago C.;Wilkinson, Adam C.;Shlush, Liran, I
成人恶性血液病，如急性髓性白血病，被认为是通过在长寿命造血干细胞（HSC）内逐渐获得致癌突变而产生的。外周血DNA的基因组分析最近在其他健康个体中鉴定了白血病相关的基因突变，这一观察结果与年龄密切相关。这些基因突变经常以高频率发现，表明突变HSC克隆的优势。还观察到携带与白血病无关的其他突变或较大染色体缺失的克隆的扩增。这种临床观察结果被称为克隆性造血，这是一种与血液恶性肿瘤和心血管疾病风险增加相关的疾病。在这里，我们讨论了克隆造血的识别及其对人类健康的影响，基于2019年5月国际实验血液学学会新研究者委员会网络研讨会。爱思唯尔公司出版代表ISEH -血液学和干细胞学会。
Adult hematological malignancies, such as acute myeloid leukemia, are thought to arise through the gradual acquisition of oncogenic mutations within long-lived hematopoietic stem cells (HSCs). Genomic analysis of peripheral blood DNA has recently identified leukemia -associated genetic mutations within otherwise healthy individuals, an observation that is strongly associated with age. These genetic mutations are often found at high frequency, suggesting dominance of a mutant HSC clone. Expansion of clones carrying other mutations not associated with leukemia or larger chromosomal deletions was also observed. This clinical observation has been termed clonal hematopoiesis, a condition associated with increased risk of both hematological malignancy and cardiovascular disease. Here, we discuss the identification of clonal hematopoiesis and its implications on human health, based on the May 2019 International Society for Experimental Hematology New Investigator Committee Webinar. Published by Elsevier Inc. on behalf of ISEH - Society for Hematology and Stem Cells.