Nicotinamide Mononucleotide Supplementation Reverses the Declining Quality of Maternally Aged Oocytes
Nicotinamide Mononucleotide Supplementation Reverses the Declining Quality of Maternally Aged Oocytes
复制标题
补充烟酰胺单核苷酸可逆转母体老化卵母细胞质量下降的情况
DOI：
10.1016/j.celrep.2020.107987
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发表时间：
2020-08-04
期刊：
影响因子：
8.8
通讯作者：
Xiong, Bo
中科院分区：
文献类型：
--
作者：
Miao, Yilong;Cui, Zhaokang;Xiong, Bo
Advanced maternal age is highly associated with a decline in oocyte quality, but effective approaches to improve it have still not been fully determined. Here, we report that in vivo supplementation of nicotinamide mononucleotide (NMN) efficaciously improves the quality of oocytes from naturally aged mice by recovering nicotinamide adenine dinucleotide (NAD(+)) levels. NMN supplementation not only increases ovulation of aged oocytes but also enhances their meiotic competency and fertilization ability by maintaining the normal spindle/chromosome structure and the dynamics of the cortical granule component ovastacin. Moreover, single-cell transcriptome analysis shows that the beneficial effect of NMN on aged oocytes is mediated by restoration of mitochondrial function, eliminating the accumulated ROS to suppress apoptosis. Collectively, our data reveal that NMN supplementation is a feasible approach to protect oocytes from advanced maternal age-related deterioration, contributing to the improvement of reproductive outcome of aged women and assisted reproductive technology.
