STREPTOZOTOCIN-INDUCED NON-INSULIN-DEPENDENT DIABETES PROTECTS THE HEART FROM INFARCTION
STREPTOZOTOCIN-INDUCED NON-INSULIN-DEPENDENT DIABETES PROTECTS THE HEART FROM INFARCTION
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DOI：
10.1161/01.cir.88.3.1273
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发表时间：
1993-09-01
期刊：
影响因子：
37.8
通讯作者：
SCHAFFER, SW
中科院分区：
文献类型：
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作者：
LIU, YG;THORNTON, JD;SCHAFFER, SW
背景。糖尿病动物的心肌对缺血性损伤的脆弱性是有争议的。为了解决这个问题，在大鼠中诱导链脲佐菌素诱导的非胰岛素依赖型糖尿病 (NIDD)，并通过测量梗塞面积来评估局部心肌缺血的影响。方法和结果。患有 NIDD 的开胸大鼠和年龄匹配的对照大鼠经历 30 或 45 分钟的局部缺血和 2 小时的再灌注。通过四唑测量梗塞面积。冠状动脉闭塞 30 分钟后，对照大鼠的危险区域有 32.0+/-3.3% 的梗塞，而 NIDD 大鼠的梗塞明显较小（危险区域的 11.5+/-3.1%，P
Background. The vulnerability of the myocardium of a diabetic animal to an ischemic insult is controversial. To address this issue, streptozotocin-induced non-insulin-dependent diabetes (NIDD) was induced in rats, and the effects of regional myocardial ischemia were assessed by measuring infarct size.Methods and Results. Open-chest rats with NIDD and age-matched control rats underwent 30 or 45 minutes of regional ischemia and 2-hour reperfusion. Infarct size was measured by tetrazolium. Control rats had 32.0+/-3.3% infarction of the risk zone after a 30-minute coronary occlusion, whereas NIDD rats had significantly smaller infarcts (11.5+/-3.1% of the risk area, P