The role of homologous recombination repair in the formation of chromosome aberrations
The role of homologous recombination repair in the formation of chromosome aberrations
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DOI：
10.1159/000077462
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发表时间：
2004-01-01
影响因子：
1.7
通讯作者：
Thacker, J
中科院分区：
文献类型：
--
作者：
Griffin, CS;Thacker, J
通过同源重组修复 DNA 双链断裂至少可以通过两种途径进行：主要无错误的 Rad51 依赖性途径，以及容易出错的 Rad51 独立途径（单链退火，SSA）。理论上，染色体交换可能是由任一途径的（错误）修复引起的。两种修复途径都将涉及同源序列的搜索，从而导致染色质的共定位。参与同源重组修复（HRR）的基因现已在小鼠体内被成功敲除，并且根据新证据讨论了HRR在染色体交换形成中的作用，特别是在电离辐射后。版权所有 (C) 2003 S. Karger AG，巴塞尔。
The repair of DNA double strand breaks by homologous recombination can occur by at least two pathways: a Rad51-dependent pathway that is predominantly error free, and a Rad51-independent pathway (single strand annealing, SSA) that is error prone. In theory, chromosome exchanges can result from (mis)repair by either pathway. Both repair pathways will involve a search for homologous sequence, leading to co-localization of chromatin. Genes involved in homologous recombination repair (HRR) have now been successfully knocked out in mice and the role of HRR in the formation of chromosome exchanges, particularly after ionising radiation, is discussed in the light of new evidence. Copyright (C) 2003 S. Karger AG, Basel.