Cell-in-cell phenomenon: A New Paradigm in Life Sciences.
Cell-in-cell phenomenon: A New Paradigm in Life Sciences.
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细胞内现象：生命科学的新范式
DOI：
10.2174/1566524015666151026095730
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发表时间：
2015
影响因子：
2.5
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Wang X
Cell-in-cell是一个或多个活细胞主动进入另一个细胞的现象，由于其在进化上的生物学意义以及在发育、稳态和疾病中的生理和病理相关性，已被观察了世纪，近年来才引起人们的关注，并正成为生物学领域的一个新的热点。本文就细胞中细胞技术的多样性、进化保守性、临床意义以及研究策略等方面的最新进展作一综述。基于本实验室和其他研究小组的研究结果，还提出了三种细胞中细胞的工作模型。
Cell-in-cell, a phenomenon characterized by one or more viable cells entering actively into another cell, was observed more than a century and has only attracted more attention in recent years and is becoming a new hot topic in the biological field, owing its biological significance in evolutionary as well as physiological and pathological relevance in development, homeostasis and diseases. In this paper we focus on the diversity, evolutionary conservatism and clinical implication of cell-in-cell as well as latest opinions on the research strategies. Based on the findings from our laboratory and other research groups three working models of cell-in-cell are also proposed.