Ocular Behçet's disease is less complicated with allergic disorders. A nationwide survey in Japan.
Ocular Behçet's disease is less complicated with allergic disorders. A nationwide survey in Japan.
复制标题
DOI：
--
复制
发表时间：
2016
影响因子：
3.7
通讯作者：
Yukihiro Horie;N. Kitaichi;Kuniaki Hijioka;K. Sonoda;Y. Saishin;T. Kezuka;H. Goto;M. Takeuchi;Satoshi Nakamura;T. Kimoto;M. Shimakawa;M. Kita;S. Sugita;M. Mochizuki;J. Hori;M. Iwata;J. Shoji;M. Fukuda;T. Kaburaki;J. Numaga;H. Kawashima;Astuki Fukushima;T. Joko;Nanae Takai;Y. Ozawa;A. Meguro;N. Mizuki;K. Namba;S. Ishida;S. Ohno
中科院分区：
文献类型：
--
作者：
Yukihiro Horie;N. Kitaichi;Kuniaki Hijioka;K. Sonoda;Y. Saishin;T. Kezuka;H. Goto;M. Takeuchi;Satoshi Nakamura;T. Kimoto;M. Shimakawa;M. Kita;S. Sugita;M. Mochizuki;J. Hori;M. Iwata;J. Shoji;M. Fukuda;T. Kaburaki;J. Numaga;H. Kawashima;Astuki Fukushima;T. Joko;Nanae Takai;Y. Ozawa;A. Meguro;N. Mizuki;K. Namba;S. Ishida;S. Ohno
behet病（BD）是一种向Th1和Th17免疫系统极化的全身性炎症性疾病。过敏性疾病是由Th2免疫系统引起的。本研究的目的是调查双相障碍患者中过敏性疾病的患病率。方法对日本21所眼科研究所的双相障碍患者进行大规模访谈调查；353例患者（男性255例，女性98例）被纳入本研究。我们分析了过敏性疾病的病史，如特应性皮炎（AD）、变应性鼻炎（AR）、支气管哮喘（BA）和药物/食物过敏（FA）。结果口腔溃疡、眼部病变、皮肤病变、生殖器溃疡、关节炎、神经系统病变、肠道病变、深静脉血栓形成和附睾炎分别占95.8%、98.6%、72.5%、44.8%、13.9%、6.8%、6.2%、3.7%和1.4%。73例（20.7%）患者有过敏性疾病史：AD（5例，1.4%）、AR（36例，10.2%）、BA（19例，5.4%）和FA（30例，8.5%）。这一比例明显低于日本厚生劳动省对健康人群进行的一项调查（47.6%）（优势比= 0.29,95%可信区间= 0.22-0.38,p=4.9×10-22）。BD患者的后/泛葡萄膜炎频率、相对严重的眼部表现和视力预后不受变应性疾病史的影响。结论：与整个日本人群相比，BD患者变应性疾病并发症较少。
OBJECTIVES Behçet's disease (BD) is a systemic inflammatory disorder polarised to the Th1 and Th17 immune systems. Allergic diseases are polarised to the Th2 immune system. The aim of the present study is to investigate the prevalence of allergic diseases in patients who have BD. METHODS The study involved a large-scale interview survey of Japanese patients with BD at 21 institutes of ophthalmology; 353 patients (255 males and 98 females) were recruited for this study. We analysed the history of allergic diseases such as atopic dermatitis (AD), allergic rhinitis (AR), bronchial asthma (BA) and drug/food allergies (FA). RESULTS Oral aphthous ulcers, ocular lesions, skin lesions, genital ulcers, arthritis, neurological lesions, intestinal lesions, deep vein thrombosis and epididymitis were reported in 95.8%, 98.6%, 72.5%, 44.8%, 13.9%, 6.8%, 6.2%, 3.7% and 1.4% of the patients, respectively. It was also reported that 73 patients (20.7%) had histories of allergic diseases: AD (5 cases, 1.4%), AR (36 cases, 10.2%), BA (19 cases, 5.4%) and FA (30 cases, 8.5%). This percentage was significantly lower than in a survey that Japan's Ministry of Health, Labour and Welfare conducted for healthy population (47.6%) (odds ratio = 0.29, 95% confidence interval = 0.22-0.38, p=4.9×10-22). Frequencies of posterior/pan-uveitis, relatively severe ocular findings, and visual prognosis were not affected by a history of allergic diseases in BD. CONCLUSIONS Patients with BD had fewer complications from allergic diseases than did the entire population of Japan.