Association of APOE polymorphisms with disease severity in MS is limited to women
Association of APOE polymorphisms with disease severity in MS is limited to women
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DOI：
10.1212/01.wnl.0000113721.83287.83
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发表时间：
2004-03-09
期刊：
影响因子：
9.9
通讯作者：
Weinshenker, BG
中科院分区：
文献类型：
--
作者：
Kantarci, OH;Hebrink, DD;Weinshenker, BG
作者研究了221名多发性硬化症患者的一个外显子4 （E4* epsilon2/3/4）和三个APOE启动子多态性与病程和严重程度（按性别分层）的关系，这些患者来自两个重叠的人群患病率队列。携带E4* epsilon2等位基因的女性需要更长的时间才能达到扩展残疾状态量表的6分（p = 0.015），并且比非携带者有更有利的严重程度评分（p = 0.009）。在男性中没有关联。等位基因epsilon3或epsilon4和启动子多态性与疾病病程或严重程度无关。
The authors studied the association of an exon 4 (E4* epsilon2/3/4) and three promoter polymorphisms of APOE with disease course and severity stratified by gender in 221 patients with multiple sclerosis from two overlapping population-based prevalence cohorts. Women carriers of the E4* epsilon2 allele took longer to attain an Expanded Disability Status Scale score of 6 ( p = 0.015) and had more favorable ranked severity scores than noncarriers ( p = 0.009). There was no association in men. Alleles epsilon3 or epsilon4 and promoter polymorphisms were not associated with disease course or severity.