New and improved ligands for highly enantioselective catalytic diphenylzinc additions to aryl aldehydes
New and improved ligands for highly enantioselective catalytic diphenylzinc additions to aryl aldehydes
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DOI：
10.1016/s0040-4039(99)02041-9
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发表时间：
2000-01-08
影响因子：
1.8
通讯作者：
Pu, L
中科院分区：
文献类型：
--
作者：
Huang, WS;Pu, L
通过在手性1，1 ′-联萘配体（R）-1上引入吸电子的氟原子，得到了一种新的催化剂（S）-5d，该催化剂对二苯基锌与醛的不对称加成反应具有较好的催化性能。这种新的配体可以在较短的反应时间和简单的反应条件下合成具有高对映选择性的手性二芳基甲醇。(C)1999 Elsevier Science Ltd.保留所有权利。
By introducing electron-withdrawing fluorine atoms to a chiral 1,1'-binaphthyl ligand (R)-1, a new catalyst (S)-5d has been obtained which shows improved catalytic properties for the asymmetric diphenylzinc addition to aldehydes. This new ligand allows the synthesis of chiral diarylcarbinols with high enantioselectivity in shorter reaction time under simple reaction conditions. (C) 1999 Elsevier Science Ltd. All rights reserved.