Quantifying temperature-dependent T1 changes in cortical bone using ultrashort echo-time MRI.
Quantifying temperature-dependent T1 changes in cortical bone using ultrashort echo-time MRI.
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DOI：
10.1002/mrm.25994
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发表时间：
2015-12
影响因子：
3.3
通讯作者：
Krug R
中科院分区：
文献类型：
--
作者：
Han M;Rieke V;Scott SJ;Ozhinsky E;Salgaonkar VA;Jones PD;Larson PE;Diederich CJ;Krug R
To demonstrate the feasibility of using ultrashort echo-time (UTE) MRI to quantify T1 changes in cortical bone due to heating. Variable flip-angle T1 mapping combined with 3D UTE imaging was used to measure T1 in cortical bone. A calibration experiment was performed to detect T1 changes with temperature in ex vivo cortical bone samples from a bovine femur. Ultrasound heating experiments were performed using an interstitial applicator in ex vivo bovine femur specimens, and heat-induced T1 changes were quantified. The calibration experiment demonstrated that T1 increases with temperature in cortical bone. We observed a linear relationship between temperature and T1 with a linear coefficient of 0.67–0.84 ms/°C over a range of 25–70°C. The ultrasound heating experiments showed increased T1 changes in the heated regions, and the relationship between the temperature changes and T1 changes was similar to that of the calibration. We demonstrated a temperature dependence of T1 in ex vivo cortical bone using a variable flip-angle UTE T1 mapping method.
