ICER-IIgamma is a tumor suppressor that mediates the antiproliferative activity of cAMP.
ICER-IIgamma is a tumor suppressor that mediates the antiproliferative activity of cAMP.
复制标题
ICER-IIgamma 是一种肿瘤抑制因子，介导 cAMP 的抗增殖活性。
作者：
Razavi,R;Ramos,JC;Yehia,G;Schlotter,F;Molina,CA
第二信使cAMP抑制大多数细胞类型的增殖。cAMP的核反应由转录因子如cAMP反应元件调节子（CREM）基因介导。CREM基因的产物之一，转录抑制因子诱导型cAMP早期抑制因子-II γ（ICER-IIγ），由cAMP诱导。ICER-IIγ在细胞周期的G2/M边界阻断细胞。在这里，我们发现ICER-IIγ显着抑制小鼠垂体瘤细胞和人绒毛膜癌细胞的生长和DNA合成。这种细胞生长的改变伴随着这些细胞以锚定非依赖性方式生长和在小鼠中形成肿瘤的能力降低。这些数据表明ICER-IIγ是介导cAMP抗增殖活性的肿瘤抑制基因产物。
The second messenger cAMP inhibits the proliferation of most cell types. The nuclear response of cAMP is mediated by transcription factors like the cAMP-Responsive Element Modulator (CREM) gene. One of the products of the CREM gene, the transcriptional repressor Inducible cAMP Early Repressor-IIγ (ICER-IIγ), is induced by cAMP. ICER-IIγ blocks cells at the G2/M boundary of the cell cycle. Here we show that ICER-IIγ dramatically inhibits the growth and DNA synthesis of mouse pituitary tumor cells and human choriocarcinoma cells. This alteration in cell growth is coupled with reduced ability of these cells to grow in an anchorage-independent manner and to form tumors in mice. These data demonstrate that ICER-IIγ is a tumor suppressor gene product mediating the antiproliferative activity of cAMP.