Toluene abuse: physical basis for hypointensity of the basal ganglia on T2-weighted MR images.
Toluene abuse: physical basis for hypointensity of the basal ganglia on T2-weighted MR images.
复制标题
甲苯滥用：T2 加权 MR 图像上基底神经节低信号的物理基础。
DOI：
10.1148/radiology.193.2.7972765
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发表时间：
1994
期刊：
影响因子：
19.7
通讯作者：
Dreisbach,J
中科院分区：
文献类型：
--
作者：
Unger,E;Alexander,A;Fritz,T;Rosenberg,N;Dreisbach,J
PURPOSETo explain the hypointensity in the basal ganglia on T2-weighted magnetic resonance (MR) images of brains of toluene abusers.MATERIALS AND METHODSEight patients with histories of toluene abuse underwent MR imaging. A bilayered model of dipalmitoylphosphatidylcholine (DPPC; 100 mmol/L concentration) and varying concentrations of toluene was formed. The DPPC control and toluene-mixed bilayers underwent MR imaging. T1 and T2 were measured as a function of toluene and lipid concentrations.RESULTST2-weighted images of patients who had abused toluene showed marked hypointensity in the thalami and moderate hypointensity in the basal ganglia. Measurements of the DPPC-toluene phantom indicated that toluene-tainted lipid bilayers dramatically shortened T2 and had little effect on T1. By comparison, DPPC itself had little discernible effect on either T1 or T2.CONCLUSIONThis model suggests that partitioning of toluene into the lipid membranes of cells in cerebral tissue may be responsible for the hypointensity of basal ganglia noted on T2-weighted MR images of brains of toluene abusers.
