CHEMOENZYMATIC SYNTHESIS OF ANALOGS OF THE 2ND-MESSENGER CANDIDATE CYCLIC ADENOSINE 5'-DIPHOSPHATE RIBOSE
CHEMOENZYMATIC SYNTHESIS OF ANALOGS OF THE 2ND-MESSENGER CANDIDATE CYCLIC ADENOSINE 5'-DIPHOSPHATE RIBOSE
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DOI：
10.1039/c39950001359
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发表时间：
1995-07-07
影响因子：
--
通讯作者：
POTTER, BVL
中科院分区：
文献类型：
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作者：
ASHAMU, GA;GALIONE, A;POTTER, BVL
通过核糖和嘌呤修饰的烟酰胺腺嘌呤二核苷酸类似物环化为环腺苷5 '-二磷酸核糖的模拟物，证明了腺苷5'-二磷酸核糖基环化酶的广泛底物特异性，从而产生了这种重要的Ca 2+动员核苷酸的结构修饰的直接途径。
A broad substrate specificity for adenosine 5'-diphosphate ribosyl cyclase is demonstrated by cyclisation of ribose- and purine-modified nicotinamide adenine dinucleotide analogues to mimics of cyclic adenosine 5'-diphosphate ribose, generating a straightforward route for structural modification of this important Ca2+-mobilising nucleotide.