Enantioselective Organocatalytic Conjugate Reduction of β-Azole-Containing α,β-Unsaturated Aldehydes
Enantioselective Organocatalytic Conjugate Reduction of β-Azole-Containing α,β-Unsaturated Aldehydes
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DOI：
10.1021/ol900893e
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发表时间：
2009-07-02
期刊：
影响因子：
5.2
通讯作者：
Cossy, Janine
中科院分区：
文献类型：
--
作者：
Hoffman, Thomas J.;Dash, Jyotirmayee;Cossy, Janine
beta-Azole-containing alpha,beta-unsaturated aldehydes were successfully reduced under highly enantioselective organocatalytic transfer hydrogenation conditions. The products were obtained in good yields and up to 94% optical purity. This simple process was successfully applied to the synthesis of the C7-C14 fragment of ulapualide A, a natural product which exhibits promising antitumor activity.
