Kinetics of Regulatory T Cells During Murine Pregnancy

Kinetics of Regulatory T Cells During Murine Pregnancy
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DOI：
10.1111/j.1600-0897.2007.00538.x
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发表时间：
2007-12
期刊：
American Journal of Reproductive Immunology
影响因子：
3.6
通讯作者：
C. Thuere;M. Zenclussen;A. Schumacher;Stefanie Langwisch;Ursula Schulte‐Wrede;A. Teles;S. Paeschke;H. Volk;A. Zenclussen
C. Thuere;M. Zenclussen;A. Schumacher;Stefanie Langwisch;Ursula Schulte‐Wrede;A. Teles;S. Paeschke;H. Volk;A. Zenclussen
中科院分区：
医学3区
文献类型：
--
作者：
C. Thuere;M. Zenclussen;A. Schumacher;Stefanie Langwisch;Ursula Schulte‐Wrede;A. Teles;S. Paeschke;H. Volk;A. Zenclussen

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Problem The semi‐allogeneic fetus is usually tolerated by the maternal immune system. This was proposed to be modulated by CD4+CD25+foxp3+ regulatory T cells (Treg). We aimed to determine the kinetics of Treg during murine gestation and investigate whether changes in Treg levels respond to hormonal variations during pregnancy or generated changes in the local indolamine dioxygenase (IDO) expression.