Sleep, sleepiness, sleep disorders and alcohol use and abuse
Sleep, sleepiness, sleep disorders and alcohol use and abuse
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DOI：
10.1053/smrv.2001.0162
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发表时间：
2001-08-01
影响因子：
10.5
通讯作者：
Roth, T
中科院分区：
文献类型：
--
作者：
Roehrs, T;Roth, T
乙醇对睡眠影响的研究由来已久，可以追溯到纳撒尼尔·克莱特曼（Nathaniel Kleitman）的研究。本文综述了大量描述乙醇对健康正常人和酗酒者睡眠影响的文献，以及描述其对白天嗜睡、睡眠期间生理功能和睡眠障碍的相互作用的最新文献。酒精最初在低剂量和高剂量下都能改善非酗酒者的睡眠，但在高剂量下会干扰他们的下半段睡眠。耐受性发展到最初的有益效果。酗酒者在饮酒和戒酒几个月后睡眠都会受到干扰，而戒酒后睡眠障碍的性质预示着复发。乙醇相互作用会加剧白天的嗜睡和睡眠呼吸障碍，甚至会导致有风险的人呼吸暂停。乙醇对睡眠中的其他生理功能和其他睡眠障碍的影响尚未被证实。(C) 2001哈考特出版有限公司
The study of ethanol's effects on sleep has a long history dating back to the work of Nathaniel Kleitman. This paper reviews the extensive literature describing ethanol's effects on the sleep of healthy normals and alcoholics and the newer literature that describes its interactive effects on daytime sleepiness, physiological functions during sleep, and sleep disorders. Ethanol initially improves sleep in non-alcoholics at both low and high doses with disturbance in the second half of the night sleep at high doses. Tolerance develops to the initial beneficial effects. In alcoholics sleep is disturbed both while drinking and for months of abstinence and the nature of the abstinent sleep disturbance is predictive of relapse. Ethanol interacts to exacerbate daytime sleepiness and sleep-disordered breathing, even inducing apnea in persons at risk. Ethanol's effects on other physiological functions during sleep and other sleep disorders has yet to be documented. (C) 2001 Harcourt Publishers Ltd.