RNA-Mediated Regulation in Pathogenic Bacteria
RNA-Mediated Regulation in Pathogenic Bacteria
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DOI：
10.1101/cshperspect.a010298
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发表时间：
2013-09-01
影响因子：
5.4
通讯作者：
Vogel, Joerg
中科院分区：
文献类型：
--
作者：
Caldelari, Isabelle;Chao, Yanjie;Vogel, Joerg
病原菌具有复杂的调控网络，在时间上控制毒力因子的产生，并使细菌能够在宿主感染后存活和增殖。调控RNA现在被认为是这些网络的重要组成部分，它们的研究不仅可以确定对抗感染性疾病的新方法，还可以揭示涉及细菌基因表达的新的一般控制机制。在这篇综述中，我们阐述了细菌病原体中调控RNA的多样性，它们的作用机制，以及它们如何被整合到调控因子产生的调控回路中。
Pathogenic bacteria possess intricate regulatory networks that temporally control the production of virulence factors, and enable the bacteria to survive and proliferate after host infection. Regulatory RNAs are now recognized as important components of these networks, and their study may not only identify new approaches to combat infectious diseases but also reveal new general control mechanisms involved in bacterial gene expression. In this review, we illustrate the diversity of regulatory RNAs in bacterial pathogens, their mechanism of action, and how they can be integrated into the regulatory circuits that govern virulence-factor production.