Effects of histamine and cholinergic systems on memory retention of passive avoidance learning in rats
Effects of histamine and cholinergic systems on memory retention of passive avoidance learning in rats
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DOI：
10.1016/s0014-2999(03)01440-7
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发表时间：
2003-03-28
影响因子：
5
通讯作者：
Parivar, K
中科院分区：
文献类型：
--
作者：
Eidi, M;Zarrindast, MR;Parivar, K
本研究探讨了组胺和胆碱能系统对成年雄性大鼠记忆保持的影响。在所有实验中进行训练后侧脑室注射。胆碱受体激动剂乙酰胆碱（1-10 μ g/大鼠）或尼古丁（1-10 μ g/大鼠）增加，而胆碱受体拮抗剂东莨菪碱（5-20 μ g/大鼠）减少记忆保持。东莨菪碱可使乙酰胆碱诱发的反应减弱。给予组胺（5-20 μ g/大鼠）可降低大鼠的记忆力，但组胺H-1受体拮抗剂吡拉明（10-50 μ g/大鼠）和组胺H-2受体拮抗剂西咪替丁（1-50 μ g/大鼠）可增加大鼠的记忆力。组胺受体拮抗剂减弱了对组胺的反应。组胺减少乙酰胆碱或尼古丁诱导的增强。组胺受体拮抗剂增强尼古丁或乙酰胆碱诱导的反应。组胺可增强东莨菪碱的抑制作用。它的结论是，组胺能和胆碱能系统对记忆保持有相反的效果。此外，组胺能系统在记忆保持中与胆碱能系统相互作用。(C)2003 Elsevier Science B. V.保留所有权利。
In the present study, the effects of the histamine and cholinergic systems on memory retention in adult male rats were investigated. Post-training intracerebroventricular injections were carried out in all the experiments. Cholinoceptor agonist, acetylcholine (1-10 mug/rat) or nicotine (1-10 mug/rat), increased, while a cholinoceptor antagonist, scopolamine (5-20 mug/rat), decreased memory retention. The response to acetylcholine was attenuated by scopolamine. Administration of histamine (5-20 mug/rat) reduced, but the histamine H-1 receptor antagonist, pyrilamine (10-50 mug/rat), and the histamine H-2 receptor antagonist, cimetidine (1-50 mug/rat), increased memory retention in rats. The histamine receptor antagonists attenuated the response to histamine. Histamine reduced the acetylcholine- or nicotine-induced enhancement. The histamine receptor antagonists enhanced the nicotine- or acetylcholine-induced response. Histamine potentiated the inhibitory effect induced by scopolamine. It is concluded that histaminergic and cholinergic systems have opposing effects on memory retention. Also, the histaminergic system elicits an interaction with the cholinergic system in memory retention. (C) 2003 Elsevier Science B.V. All rights reserved.