Vocal babbling in songbirds requires the basal ganglia-recipient motor thalamus but not the basal ganglia
Vocal babbling in songbirds requires the basal ganglia-recipient motor thalamus but not the basal ganglia
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DOI：
10.1152/jn.00823.2010
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发表时间：
2011-06-01
影响因子：
2.5
通讯作者：
Fee, Michale S.
中科院分区：
文献类型：
--
作者：
Goldberg, Jesse H.;Fee, Michale S.
Goldberg JH，Fee MS.鸣禽的发声需要基底神经节受体运动丘脑，但不需要基底神经节。J Neurophysiol 105：2729-2739，2011.首次发表于2011年3月23日; doi：10.1152/jn.00823.2010.-年轻的鸣鸟发出声音“咿呀学语”，它们的歌声的可变性被认为是一个试错式声乐学习过程的基础。众所周知，这种探索性的变异性需要基底神经节（BG）丘脑皮质环的“皮质”成分，但对BG和丘脑成分在这种行为中的作用了解较少。我们发现，大型双边病变鸣禽BG同源区域X有很少或没有影响的歌曲变异性在声乐咿呀学语。与此相反，病变的BG受体丘脑核DLM（内侧部分的背外侧丘脑）在很大程度上废除了正常的声乐咿呀学语的幼鸟，并造成了显着增加的歌曲刻板。这些发现支持了运动丘脑在探索性少年行为的表达中起着关键作用的观点。
Goldberg JH, Fee MS. Vocal babbling in songbirds requires the basal ganglia-recipient motor thalamus but not the basal ganglia. J Neurophysiol 105: 2729-2739, 2011. First published March 23, 2011; doi:10.1152/jn.00823.2010.-Young songbirds produce vocal "babbling," and the variability of their songs is thought to underlie a process of trial-and-error vocal learning. It is known that this exploratory variability requires the "cortical" component of a basal ganglia (BG) thalamocortical loop, but less understood is the role of the BG and thalamic components in this behavior. We found that large bilateral lesions to the songbird BG homolog Area X had little or no effect on song variability during vocal babbling. In contrast, lesions to the BG-recipient thalamic nucleus DLM (medial portion of the dorsolateral thalamus) largely abolished normal vocal babbling in young birds and caused a dramatic increase in song stereotypy. These findings support the idea that the motor thalamus plays a key role in the expression of exploratory juvenile behaviors during learning.