How the Dorsal gradient works: Insights from postgenome technologies
How the Dorsal gradient works: Insights from postgenome technologies
复制标题
DOI：
10.1073/pnas.0806476105
复制
发表时间：
2008-12-23
影响因子：
11.1
通讯作者：
Levine, Michael S.
中科院分区：
文献类型：
--
作者：
Hong, Joung-Woo;Hendrix, David A.;Levine, Michael S.
细胞外信号分子和转录因子的梯度作用于多种发育过程，包括果蝇胚胎的模式化，脊椎动物神经管中不同神经元细胞类型的建立，以及脊椎动物四肢的前后模式。在这里，我们讨论了母体转录因子Dorsal的梯度如何在早期果蝇胚胎的背-腹（DV）轴上产生复杂的基因表达模式。60-70个背侧靶基因的鉴定，以及大约35个相关调控dna的表征，表明至少有6种不同的调控代码驱动不同的DV表达谱。
Gradients of extracellular signaling molecules and transcription factors are used in a variety of developmental processes, including the patterning of the Drosophila embryo, the establishment of diverse neuronal cell types in the vertebrate neural tube, and the anterior-posterior patterning of vertebrate limbs. Here, we discuss how a gradient of the maternal transcription factor Dorsal produces complex patterns of gene expression across the dorsal-ventral (DV) axis of the early Drosophila embryo. The identification of 60-70 Dorsal target genes, along with the characterization of approximate to 35 associated regulatory DNAs, suggests that there are at least six different regulatory codes driving diverse DV expression profiles.