INFLUENCE OF MENOPAUSE ON SERUM-LIPIDS AND LIPOPROTEINS
INFLUENCE OF MENOPAUSE ON SERUM-LIPIDS AND LIPOPROTEINS
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DOI：
10.1016/0378-5122(90)90012-u
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发表时间：
1990-11-01
期刊：
影响因子：
4.9
通讯作者：
CHRISTIANSEN, C
中科院分区：
文献类型：
--
作者：
JENSEN, J;NILAS, L;CHRISTIANSEN, C
在绝经前妇女中，每隔6周纵向检查绝经对血脂和脂蛋白的影响，持续2-3年。对绝经前、围绝经期和绝经后的4组妇女进行了血脂和脂蛋白的横断面检测，每3个月进行一次纵向随访，随访1-2年。本文报告了1360例检查和270例妇女年的结果。血清总胆固醇（P = 0.001）、低密度脂蛋白（LDL）胆固醇（P = 0.001）和甘油三酯（P < 0.05）浓度因绝经而显著升高，且均在月经停止后6个月内升高。绝经后高密度脂蛋白（HDL）胆固醇显著下降（P < 0.05），但在月经停止前2年内逐渐下降。除绝经期变化外，血清总胆固醇和低密度脂蛋白胆固醇浓度在绝经前和绝经后逐渐升高，但仅绝经前组与生物学年龄显著相关（P < 0.05）。血清甘油三酯和高密度脂蛋白胆固醇水平在绝经前和绝经后的人群中几乎保持不变，只受实际绝经的影响。血清脂质和脂蛋白因此显著改变作为更年期的后果。其结果是一个更具有动脉粥样硬化性的脂质谱，这可能部分解释了绝经后妇女患心血管疾病的风险增加。
The influence of the menopause on serum lipids and lipoproteins was examined longitudinally at 6-week intervals for 2-3 years in pre-menopausal women undergoing the menopause. Serum lipid and lipoprotein profiles were also examined cross-sectionally in 4 groups of pre-menopausal, perimenopausal and post-menopausal women, who were followed up longitudinally at 3-monthly examinations for 1-2 years. The results covering 1360 examinations and 270 woman-years are reported here. Serum concentrations of total cholesterol (P = 0.001), low-density-lipoprotein (LDL) cholesterol (P = 0.001) and triglycerides (P < 0.05) increased significantly as a consequence of the menopause and all increases occurred within 6 months of cessation of menstrual periods. High-density-lipoprotein (HDL) cholesterol decreased significantly (P < 0.05) as a consequence of the menopause, but the decline occurred gradually over the 2 years preceding cessation of menses. In addition to the menopausal changes, serum concentrations of total cholesterol and LDL-cholesterol increased gradually in the pre-menopausal and post-menopausal years, but were significantly related to biological age only in the pre-menopausal groups (P < 0.05). Serum triglycerides and HDL-cholesterol levels remained virtually unchanged in the pre-menopausal as well as the post-menopausal groups and were only influenced by the actual menopause. Serum lipids and lipoporteins were thus significantly altered as a consequence of the menopause. The results is a more atherogenic lipid profile which may partly explain the increased risk of cardiovascular disease observed in post-menopausal women.