Quantitative Imaging Biomarkers of NAFLD.
Quantitative Imaging Biomarkers of NAFLD.
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DOI：
10.1007/s10620-016-4037-1
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发表时间：
2016-05
影响因子：
3.1
通讯作者：
Yokoo T
中科院分区：
文献类型：
--
作者：
Kinner S;Reeder SB;Yokoo T
传统的成像方式，包括超声（US）、计算机断层扫描（CT）和磁共振（MR），通过对肝脂肪变性进行无创诊断，在非酒精性脂肪性肝病（NAFLD）患者的诊断和治疗中发挥着重要作用。然而，由于多种原因，传统成像方式作为NAFLD的生物标志物存在局限性。多参数定量磁共振成像技术克服了传统成像的许多缺点，能够对NAFLD进行全面、客观的评估。磁共振成像可在单次检查中提供无混杂因素的肝脏脂肪、铁和纤维化的生物标志物——虚拟活检已成为临床现实。在本文中，我们将综述传统超声、CT和磁共振成像在NAFLD诊断中的应用及局限性。还将讨论NAFLD成像生物标志物的最新进展，重点是多参数定量磁共振成像。
Conventional imaging modalities, including ultrasonography (US), computed tomography (CT), and magnetic resonance (MR), play an important role in the diagnosis and management of patients with nonalcoholic fatty liver disease (NAFLD) by allowing noninvasive diagnosis of hepatic steatosis. However, conventional imaging modalities are limited as biomarkers of NAFLD for various reasons. Multi-parametric quantitative MRI techniques overcome many of the shortcomings of conventional imaging and allow comprehensive and objective evaluation of NAFLD. MRI can provide unconfounded biomarkers of hepatic fat, iron, and fibrosis in a single examination—a virtual biopsy has become a clinical reality. In this article, we will review the utility and limitation of conventional US, CT, and MR imaging for the diagnosis NAFLD. Recent advances in imaging biomarkers of NAFLD are also discussed with an emphasis in multi-parametric quantitative MRI.