Protein redistribution diet restores motor function in patients with dopa‐resistant “off” periods
Protein redistribution diet restores motor function in patients with dopa‐resistant “off” periods
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DOI：
10.1212/wnl.38.3.481
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发表时间：
1988-03
期刊：
影响因子：
9.9
通讯作者：
J. Pincus;K. Barry
中科院分区：
文献类型：
--
作者：
J. Pincus;K. Barry
16名帕金森病患者在获得性耐药的“关闭”期没有运动障碍，他们被安排在一种几乎所有蛋白质都集中在晚餐的饮食中。对左旋多巴的敏感性恢复率为88%。10名患者（62%）继续遵守饮食7个月（平均）。对两名患者进行了详细研究。不动与血浆大分子中性氨基酸（LNAA）水平升高相关，正常与低LNAA相关。
Sixteen parkinsonians with acquired drug-resistant "off" periods without dyskinesia were placed on a diet in which virtually all protein was concentrated in the evening meal. Restoration of sensitivity to levodopa resulted in 88%. Ten patients (62%) have continued to comply with the diet for 7 months (mean). Two patients were studied in detail. Immobility correlated with elevated plasma levels of large neutral amino acids (LNAA), normality with low LNAA.