Topographic mapping of a hierarchy of temporal receptive windows using a narrated story.
Topographic mapping of a hierarchy of temporal receptive windows using a narrated story.
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DOI：
10.1523/jneurosci.3684-10.2011
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发表时间：
2011-02-23
期刊：
影响因子：
--
通讯作者：
Hasson U
中科院分区：
文献类型：
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作者：
Lerner Y;Honey CJ;Silbert LJ;Hasson U
真实的生活活动，如看电影或参与谈话，展开了许多分钟。在这些活动的过程中，大脑必须在多个时间尺度上整合信息。我们最近提出，大脑使用类似的策略来整合跨空间和时间的信息。与空间感受野（SRF）平行，我们将皮层微回路的时间感受窗（TRW）定义为反应之前感觉信息可能影响该反应的时间长度。我们以前在视觉系统中的发现与TRW从低级感觉区域移动到高级感知和认知区域时变大的假设是一致的。在这项研究中，我们通过测量受试者在听一个真实的生活故事时的fMRI活动，绘制了听觉和语言区域的TRW。我们的研究结果揭示了TRW的层次拓扑结构。在早期听觉皮层（A1+）中，大脑反应主要由瞬时输入驱动，并且在所有干扰条件下都同样可靠。在具有中间TRW的区域中，在句子时间尺度或更长的时间尺度上的连贯信息对于唤起可靠的反应是必要的。在TRW层级的顶端，我们发现顶叶和额叶区域只有在完整的段落以有意义的顺序被听到时才能做出可靠的反应。这些结果表明，时间尺度的处理是一个功能属性，可以提供一个一般的组织原则，为人类大脑皮层。
Real life activities, such as watching a movie or engaging in conversation, unfold over many minutes. In the course of such activities the brain has to integrate information over multiple time scales. We recently proposed that the brain uses similar strategies for integrating information across space and over time. Drawing a parallel with spatial receptive fields (SRF), we defined the temporal receptive window(TRW) of a cortical microcircuit as the length of time prior to a response during which sensory information may affect that response. Our previous findings in the visual system are consistent with the hypothesis that TRWs become larger when moving from low-level sensory to high-level perceptual and cognitive areas. In this study, we mapped TRWs in auditory and language areas by measuring fMRI activity in subjects listening to a real life story scrambled at the time scales of words, sentences and paragraphs. Our results revealed a hierarchical topography of TRWs. In early auditory cortices (A1+), brain responses were driven mainly by the momentary incoming input and were similarly reliable across all scrambling conditions. In areas with an intermediate TRW, coherent information at the sentence time scale or longer was necessary to evoke reliable responses. At the apex of the TRW hierarchy we found parietal and frontal areas which responded reliably only when intact paragraphs were heard in a meaningful sequence. These results suggest that the time scale of processing is a functional property that may provide a general organizing principle for the human cerebral cortex.