Changes in dopamine availability in the nigrostriatal and mesocortical dopaminergic systems by gait in Parkinson's disease
Changes in dopamine availability in the nigrostriatal and mesocortical dopaminergic systems by gait in Parkinson's disease
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DOI：
10.1093/brain/124.4.784
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发表时间：
2001-04-01
期刊：
影响因子：
14.5
通讯作者：
Tanaka, K
中科院分区：
文献类型：
--
作者：
Ouchi, Y;Kanno, T;Tanaka, K
基底神经节在控制步态运动中发挥作用，本研究的目的是研究6名正常受试者和7名年龄匹配的帕金森病患者的纹状体和纹状体外区多巴胺转运体（DAT）可用性与步行运动的关系，这是通过使用I）AT探针比较步态后多巴胺能投射区中DAT放射性配体的摄取与静息条件下的摄取来完成的，C-11标记的2-β-甲氧羰基-3 β-（4-氟苯基）托烷（[C-11]CFT）和PET，两组的生理参数在步态期间和之后稳定。用于测量[C-11]CFT摄取水平差异的感兴趣区域方法和基于体素的统计参数映射（SPM 96）表明，纹状体中[C-11]CFT摄取（特别是壳核）在正常受试者中因步态而降低的程度更大，而帕金森病患者的[C-11]CFT摄取在尾状核和眶额皮质没有显著减少。这些结果是第一个在体内的证据表明，DAT的可用性减少在黑质纹状体投射区的基本人类行为，即步态。帕金森病患者的这种可用性的改变表明，内侧纹状体和中皮质多巴胺能系统的激活可能反映了帕金森病步态的病理生理学。
The basal ganglia play a role in controlling movement during gait, The aim of the present study was to investigate changes in dopamine transporter (DAT) availability in the striatum and extrastriatal region in association with walking exercise in six normal subjects and seven age-matched unmedicated patients with Parkinson's disease, This was done by comparing DAT radioligand uptake in the dopaminergic projection areas after gait with that under the resting condition using a I)AT probe, C-11-labelled 2-beta -carbomethoxy-3 beta-(4-fluorophenyl) tropane ([C-11]CFT) and PET, Physiological parameters were stable during and after gait in both groups. The regions of interest method for measuring differences in [C-11]CFT uptake level and voxel-based statistical parametric mapping (SPM96) showed that [C-11]CFT uptake in the striatum (specifically the putamen) was decreased by gait to a greater extent in normal subjects, whereas a significant reduction in [C-11]CFT uptake was not found in the putamen but in the caudate and orbitofrontal cortex in Parkinson's disease patients. These results are the first in vivo evidence that DAT availability is reduced in the nigrostriatal projection area by basic human behaviour, i.e. gait. Alterations in this availability in Parkinson's disease suggested that shifted activation in the medial striatum and the mesocortical dopaminergic system might reflect the pathophysiology of parkinsonian gait.