Resveratrol commonly displays hormesis: Occurrence and biomedical significance
Resveratrol commonly displays hormesis: Occurrence and biomedical significance
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DOI：
10.1177/0960327110383625
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发表时间：
2010-12-01
影响因子：
2.8
通讯作者：
Calabrese, Vittorio
中科院分区：
文献类型：
--
作者：
Calabrese, Edward J.;Mattson, Mark P.;Calabrese, Vittorio
白藜芦醇在广泛的生物模型中诱导兴奋剂量反应，影响许多具有生物医学和治疗意义的终点。据报道，许多影响乳腺、前列腺、结肠、肺、子宫和白血病的人类肿瘤细胞系都有这些反应。在这种情况下，低浓度的白藜芦醇促进肿瘤细胞的增殖，而高浓度的白藜芦醇抑制肿瘤细胞的增殖。在包括利什曼病和旋毛虫在内的几种寄生虫病中，也看到了类似的白藜芦醇诱导的双相剂量反应。在心血管损伤、胃损伤、缺血性中风、阿尔茨海默病和骨质疏松症的动物模型中也有兴奋效应的报道。在这些情况下，通常在低剂量时有保护作用，但在高剂量时会产生不良影响，从而加剧疾病进程/发病率。这一分析表明，白藜芦醇引起的许多效应与剂量有关，而低剂量和高剂量时出现相反的效应，这表明白藜芦醇具有兴奋的剂量反应。尽管白藜芦醇在广泛的生物医学模型中持续出现兴奋剂量反应，但仍需要流行病学和临床试验来评估其在人体内的剂量反应性质。
Resveratrol induces hormetic dose responses in a wide range of biological models, affecting numerous endpoints of biomedical and therapeutic significance. These responses were reported for numerous human tumor cell lines affecting breast, prostate, colon, lung, uterine and leukemia. In such cases, low concentrations of resveratrol enhanced tumor cell proliferation whereas higher concentrations were inhibitory. Similar resveratrol-induced biphasic dose responses were seen with several parasitic diseases, including Leishmaniasis and trichinella. Hormetic effects were also reported in animal models for cardiovascular induced injury, gastric lesions, ischemic stroke, Alzheimer's disease and osteoporosis. In these cases, there was often a protective effect at low doses but an adverse effect at higher doses, exacerbating the disease process/incidence. This analysis indicates that many effects induced by resveratrol are dependent on dose and that opposite effects occur at low and high doses, being indicative of a hormetic dose response. Despite consistent occurrence of hormetic dose responses of resveratrol in a wide range of biomedical models, epidemiologic and clinical trials are needed to assess the nature of its dose-response in humans.