Analysis of the Particle Formation Process of Structured Microparticles
Analysis of the Particle Formation Process of Structured Microparticles
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DOI：
10.1021/mp500758s
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发表时间：
2015-08-01
影响因子：
4.9
通讯作者：
Vehring, Reinhard
中科院分区：
文献类型：
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作者：
Baldelli, Alberto;Boraey, Mohammed A.;Vehring, Reinhard
从实验和理论上研究了乙酸丁酸纤维素在丙酮溶液中干燥成粒的过程。使用单分散液滴链产生尺寸范围为55-70 μ m的溶液微滴，溶液浓度为0.37和10 mg/mL。当液滴在温度为30、40或55摄氏度的层流空气流中干燥时，通过两种独立的光学方法记录颗粒形成过程。收集尺寸范围为10-30 μ m的干燥颗粒用于形态分析，显示中空的细长颗粒，其结构取决于干燥气体温度和初始溶液浓度。该装置允许进行颗粒形成过程的全面测量，包括初始壳形成后的时间。该系统的早期颗粒形成过程是由醋酸丁酸纤维素在液相中的扩散控制的，而该过程的后期阶段主要是由壳屈曲和折叠。
The particle formation process for microparticles of cellulose acetate butyrate dried from an acetone solution was investigated experimentally and theoretically. A monodisperse droplet chain was used to produce solution microdroplets in a size range of 55-70 mu m with solution concentrations of 0.37 and 10 mg/mL. As the droplets dried in a laminar air flow with a temperature of 30, 40, or 55 degrees C, the particle formation process was recorded by two independent optical methods. Dried particles in a size range of 10-30 mu m were collected for morphology analysis, showing hollow, elongated particles whose structure was dependent on the drying gas temperature and initial solution concentration. The setup allowed comprehensive measurements of the particle formation process to be made, including the period after initial shell formation. The early particle formation process for this system was controlled by the diffusion of cellulose acetate butyrate in the liquid phase, whereas later stages of the process were dominated by shell buckling and folding.