Effect of exercise on in vitro immune function: a 12-month randomized, controlled trial among postmenopausal women
Effect of exercise on in vitro immune function: a 12-month randomized, controlled trial among postmenopausal women
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DOI：
10.1152/japplphysiol.01349.2007
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发表时间：
2008-06-01
影响因子：
3.3
通讯作者：
Ulrich, Cornelia M.
中科院分区：
文献类型：
--
作者：
Campbell, Peter T.;Wener, Mark H.;Ulrich, Cornelia M.
横断面研究表明，适度的体力活动与增强静息免疫功能有关;然而，很少有随机对照试验研究这种联系。我们对115名年龄在50-75岁的绝经后、超重或肥胖的久坐妇女进行了一项随机对照试验，研究了12个月有氧运动相对于拉伸对照对体外免疫功能的影响。运动目标为>= 45分钟/天，5天/周。对照组妇女参加1天/周的拉伸课程。根据严格的抽血标准，在基线、3个月和12个月时评估免疫标志物（自然杀伤细胞细胞毒性、T淋巴细胞增殖、免疫细胞计数和表型以及血清免疫球蛋白）。一般估计方程评估了3个月和12个月时的干预效果，控制了基线。在开始试验的115名妇女中，有109名（95%）在3个月时和108名（94%）在12个月时提供了血液样本。从基线到12个月，运动组每周参加87%的规定体力活动分钟，最大O-2摄取量增加13.8%;对照组的健康状况没有变化。3个月和12个月时，两组的主要结果（自然杀伤细胞细胞毒性和T淋巴细胞增殖）没有差异。次要结局和亚组（e。例如，在一个实施例中，按体重指数、免疫状态、C反应蛋白和年龄的基线分类分层）分析未显示任何明确的相关模式。这项为期12个月的随机对照试验显示，有氧运动对体外免疫功能没有影响，尽管运动干预具有良好的保持力、高依从性和明显的疗效。
Cross-sectional studies suggest that moderate physical activity is associated with enhanced resting immune function; however, few randomized controlled trials have investigated this link. We investigated the effect of 12-mo aerobic exercise, relative to stretching control, on in vitro immune function in a randomized, controlled trial of 115 postmenopausal, overweight, or obese sedentary women, aged 50-75 yr. The exercise goal was >= 45 min/day, 5 days/wk. Control women participated in 1 day/wk stretching classes. Immune markers (natural killer cell cytotoxicity, T-lymphocyte proliferation, immune cell counts and phenotypes, and serum immunoglobulins) were assessed at baseline, 3 mo, and 12 mo under strict blood-draw criteria. General estimation equations evaluated intervention effects at 3 and 12 mo, controlling for baseline. Of the 115 women who began the trial, blood samples were available from 109 at 3 mo (95%) and 108 at 12 mo (94%). From baseline to 12 mo, the exercise group participated in 87% of the prescribed physical activity minutes per week and increased maximal O-2 uptake by 13.8%; controls experienced no change in fitness. The main outcomes, natural killer cell cytotoxicity and T-lymphocyte proliferation, did not differ between groups at 3 and 12 mo. Secondary outcome and subgroup (e. g., stratification by baseline categories of body mass index, immune status, C-reactive protein, and age) analyses did not show any clear patterns of association. This 12-mo randomized, controlled trial showed no effect of aerobic exercise on in vitro immune function, despite excellent retention, high adherence, and demonstrable efficacy of the exercise intervention.