The role of C-reactive protein as a prognostic indicator in advanced cancer.
The role of C-reactive protein as a prognostic indicator in advanced cancer.
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DOI：
10.1007/s11912-002-0023-1
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发表时间：
2002-05-01
影响因子：
4.7
通讯作者：
Rivera, Nilo I
中科院分区：
文献类型：
--
作者：
Mahmoud, Fade Aziz;Rivera, Nilo I
c反应蛋白(CRP)是一种非特异性但敏感的炎症标志物。白细胞介素-6 （IL-6）、IL-1和肿瘤坏死因子α诱导肝细胞中CRP的合成。CRP水平升高被认为是动脉粥样硬化、心肌梗死、外周血管疾病和缺血性中风的重要危险因素。它与体重减轻、厌食症-恶病质综合征、疾病程度和晚期癌症复发呈正相关。它在多发性骨髓瘤、黑色素瘤、淋巴瘤、卵巢、肾脏、胰腺和胃肠道肿瘤中作为生存预测因子的作用已被证实。测量CRP是一种简单、廉价、常规的方法，可为姑息治疗提供有价值的信息。
C-reactive protein (CRP) is a nonspecific but sensitive marker of inflammation. Interleukin-6 (IL-6), IL-1, and tumor necrosis factor alpha induce the synthesis of CRP in hepatocytes. Increased CRP level is considered to be an important risk factor for atherosclerosis, myocardial infarction, peripheral vascular disease, and ischemic stroke. It is positively correlated with weight loss, anorexia-cachexia syndrome, extent of disease, and recurrence in advanced cancer. Its role as a predictor of survival has been shown in multiple myeloma, melanoma, lymphoma, ovarian, renal, pancreatic, and gastrointestinal tumors. Measurement of CRP is simple, cheap, and routine and provides valuable information in palliative care.