Network Activity Underlying the Illusory Self-Attribution of a Dummy Arm
Network Activity Underlying the Illusory Self-Attribution of a Dummy Arm
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DOI：
10.1002/hbm.22770
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发表时间：
2015-06-01
影响因子：
4.8
通讯作者：
Blankenburg, Felix
中科院分区：
文献类型：
--
作者：
Limanowski, Jakub;Blankenburg, Felix
神经影像学已经证明，身体部位的虚幻自我归因涉及额叶和顶叶内脑区，最近的证据进一步表明，在枕颞皮层的视觉身体选择区域也参与其中。然而，人们对这个网络中信息交换的原理知之甚少。在这项研究中，我们使用对参与者右臂不同解剖位置的自动一致与不一致的视觉刺激，并在功能磁共振成像扫描仪中使用一个真实的假臂，诱导假臂的虚幻自我归因。这种错觉持续激活左半球网络，包括腹侧运动前皮层（PMv）、顶叶内沟（IPS）和外侧枕颞皮质（LOC）的身体选择区域。重要的是，在错觉期间，PMv和IPS与LOC的功能耦合显著增加，动态因果模型显示LOC和次级体感皮层到IPS的连接显著增强。这些结果符合大脑的推理机制依赖于预测误差的分层传播的观点。在虚幻自我归因过程中，关于身体结构的不可预测的模糊感觉输入可能导致视觉和体感区域产生这种预测错误，这些预测错误可能被传递到顶叶整合区。中国生物医学工程学报（英文版），2015。(c) 2015 Wiley期刊公司
Neuroimaging has demonstrated that the illusory self-attribution of body parts engages frontal and intraparietal brain areas, and recent evidence further suggests an involvement of visual body-selective regions in the occipitotemporal cortex. However, little is known about the principles of information exchange within this network. Here, using automated congruent versus incongruent visuotactile stimulation of distinct anatomical locations on the participant's right arm and a realistic dummy counterpart in an fMRI scanner, we induced an illusory self-attribution of the dummy arm. The illusion consistently activated a left-hemispheric network comprising ventral premotor cortex (PMv), intraparietal sulcus (IPS), and body-selective regions of the lateral occipitotemporal cortex (LOC). Importantly, during the illusion, the functional coupling of the PMv and the IPS with the LOC increased substantially, and dynamic causal modeling revealed a significant enhancement of connections from the LOC and the secondary somatosensory cortex to the IPS. These results comply with the idea that the brain's inference mechanisms rely on the hierarchical propagation of prediction error. During illusory self-attribution, unpredicted ambiguous sensory input about one's body configuration may result in the generation of such prediction errors in visual and somatosensory areas, which may be conveyed to parietal integrative areas. Hum Brain Mapp 36:2284-2304, 2015. (c) 2015 Wiley Periodicals, Inc.