Chronic neural stimulation with thin-film, iridium oxide electrodes
Chronic neural stimulation with thin-film, iridium oxide electrodes
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DOI：
10.1109/10.846685
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发表时间：
2000-07-01
影响因子：
4.6
通讯作者：
Anderson, DJ
中科院分区：
文献类型：
--
作者：
Weiland, JD;Anderson, DJ
进行实验以评估慢性刺激对电极-组织系统的电特性的影响，如使用电化学阻抗谱（EIS）和循环伏安法（CV）测量的。将带有多个氧化铱刺激电极（400-1600 μ m（2））的硅微加工探针植入豚鼠皮层，术后10-17天恢复期后，进行5天单极刺激，每天2小时/电极，使用双相恒定电流刺激（5-100 μ A，100 μ s/相）。在刺激前后采集EIS和CV数据。刺激后阻抗[在中频（100 Hz-100 kHz）下]相对于刺激前水平持续显著降低。阻抗幅值在低频下永久性增加（
Experiments were conducted to assess the effect of chronic stimulation on the electrical properties of the electrode-tissue system, as measured using electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). Silicon, micromachined probes with multiple iridium oxide stimulating electrodes (400-1600 mu m(2)) were implanted in guinea pig cortex, A 10-17 day post-operative recovery period was followed by five days of monopolar stimulation, two hours/electrode each day using biphasic, constant current stimulation (5-100 mu A, 100 mu s/phase). EIS and CV-data were taken before and after stimulation. The post-stimulation impedance [at mid-range frequencies (100 Hz-100 kHz)] consistently and significantly decreased relative to prestimulation levels. Impedance magnitude increased permanently at low frequencies (