Value of serum procalcitonin, neopterin, and C-reactive protein in differentiating bacterial from viral etiologies in patients presenting with lower respiratory tract infections
Value of serum procalcitonin, neopterin, and C-reactive protein in differentiating bacterial from viral etiologies in patients presenting with lower respiratory tract infections
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DOI：
10.1016/j.diagmicrobio.2007.04.019
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发表时间：
2007-10-01
影响因子：
2.9
通讯作者：
Chan, Paul K. S.
中科院分区：
文献类型：
--
作者：
Ip, Margaret;Rainer, Timothy H.;Chan, Paul K. S.
评估了降钙素原 (PCT)、新蝶呤和 C 反应蛋白 (CRP) 单独和联合使用在下呼吸道感染 (LRTI) 患者中区分细菌和病毒病因的价值。对 139 名确诊为细菌性病因的患者和 128 名病毒性病因的患者在住院当天采集的血清进行了检查。另外 146 份来自未感染的健康中国受试者的血清被纳入对照。用于区分细菌和病毒感染的受试者工作特征 (ROC) 曲线下面积（曲线下面积 [AUC]）对于 CRP 为 0.838，对于 PCT 为 0.770（P < 0.05）。新蝶呤区分病毒和细菌感染的 AUC 为 0.832（P < 0.05）。当标记物组合使用时，ROC（CRP/新蝶呤）的AUC为0.857，而（CRP×PCT）/新蝶呤为0.856。 2 种或全部 3 种生物标志物的组合可以提高区分 LRTI 中细菌与病毒病因的区分能力。 (C) 2007 Elsevier Inc. 保留所有权利。
The values of procalcitonin (PCT), neopterin, and C-reactive protein (CRP) alone and in combination to differentiate bacterial from viral etiology in patients with lower respiratory tract infections (LRTIs) were evaluated. Sera obtained on the day of hospitalization for LRTI from 139 patients with confirmed bacterial etiology and 128 patients with viral etiology were examined. A further 146 sera from healthy Chinese subjects with no infection were included as controls. The area under the receiver operating characteristic (ROC) curve (area under curve [AUC]) for distinguishing bacterial from viral infections was 0.838 for CRP and 0.770 for PCT (P < 0.05). The AUC for distinguishing viral from bacterial infections was 0.832 for neopterin (P < 0.05). When the markers were used in combination, AUC of ROC (CRP/neopterin) was 0.857, whereas (CRP x PCT)/neopterin was 0.856. Combination of 2 or all 3 of the biomarkers may improve the discriminatory power in delineating bacterial versus viral etiology in LRTI. (C) 2007 Elsevier Inc. All rights reserved.