Childhood uric acid predicts adult blood pressure - The Bogalusa Heart Study
Childhood uric acid predicts adult blood pressure - The Bogalusa Heart Study
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DOI：
10.1161/01.hyp.0000150783.79172.bb
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发表时间：
2005-01-01
期刊：
影响因子：
8.3
通讯作者：
Hamm, LL
中科院分区：
文献类型：
--
作者：
Alper, AB;Chen, W;Hamm, LL
尿酸已被认为是人类原发性高血压发展的重要危险因素。然而，有关儿童尿酸水平和成年血压水平的信息有限。这项研究检查了参加博加卢萨心脏研究的334名白人和243名黑人，他们是5至17岁的儿童和18至35岁的成年人。平均随访时间为12年。儿童期尿酸与儿童期和成人期收缩压和舒张压显著相关。在多变量回归分析中，校正年龄、性别、种族、儿童期体重指数、儿童期尿酸水平和尿酸水平变化是成人舒张压的重要预测因子，而尿酸变化是成人收缩压的重要预测因子。总之，儿童期血清尿酸水平升高与儿童期开始的血压升高以及持续至成年期的高血压水平相关，男性和女性，白人和黑人，表明血清尿酸水平早期升高可能在人类高血压的发展中起关键作用。
Uric acid has been proposed as an important risk factor in the development of primary hypertension in humans. However, limited information is available linking childhood uric acid levels and blood pressure levels in adulthood. This study examined 334 whites and 243 blacks enrolled in the Bogalusa Heart Study as children aged 5 to 17 years and as adults aged 18 to 35 years. The average follow-up period was 12 years. Childhood uric acid was significantly correlated with childhood and adult blood pressure, both systolic and diastolic. In a multivariate regression analysis, adjusting for age, sex, race, childhood body mass index, childhood uric acid levels, and change in levels of uric acid were significant predictors of adult diastolic blood pressure, whereas change in uric acid was a significant predictor of adult systolic blood pressures. In conclusion, elevated childhood serum uric acid levels are associated with increased blood pressure beginning in childhood and higher blood pressure levels that persist into adulthood, in males and females, whites and blacks, suggesting that early elevations in serum uric acid levels may play a key role in the development of human hypertension.