Reduced Size of Retinal Ganglion Cell Axons and Hypomyelination in Mice Lacking Brain-Derived Neurotrophic Factor
Reduced Size of Retinal Ganglion Cell Axons and Hypomyelination in Mice Lacking Brain-Derived Neurotrophic Factor
复制标题
缺乏脑源性神经营养因子的小鼠视网膜神经节细胞轴突尺寸减小和髓鞘形成低下
DOI：
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发表时间：
1997
影响因子：
3.5
通讯作者：
Y. Barde
中科院分区：
文献类型：
--
作者：
A. Cellerino;P. Carroll;H. Thoenen;Y. Barde
While brain-derived neurotrophic factor (BDNF) delays the death of axotomized retinal ganglion cells in rodents, it is unclear if it affects any aspect of the normal development of these cells. Here we examined the optic nerve of bdnf-/- mice. Axonal numbers were normal, but their diameter, as well as the proportion of myelinated axons, was reduced at postnatal day 20 (P20). In contrast, the facial nerve was not hypomyelinated. Expression levels of mRNAs coding for the myelin proteins PLP and MBP were substantially reduced in the hippocampus and cortex at P20, but not in the sciatic nerve. Intraventricular injections of BDNF into the ventricles of wild-type mice at P10 and P12 up-regulated expression of PLP in the hippocampus at P14. These results indicate a role of BDNF, discussed as indirect, in the control of myelination in the central nervous system.
BDNF 在小鸡视网膜中控制早期细胞死亡。
DOI：
10.1242/dev.124.17.3313
发表时间：
1997
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Frade,JM;Bovolenta,P;Martínez-Morales,JR;Arribas,A;Barbas,JA;Rodríguez-Tébar,A
通讯作者：
Rodríguez-Tébar,A
影响因子：
4.4
作者：
P. Peinado-Ramon;M. Salvador;M. Villegas-Pérez;M. Vidal-Sanz
通讯作者：
P. Peinado-Ramon;M. Salvador;M. Villegas-Pérez;M. Vidal-Sanz