High-dose dietary zinc promotes prostate intraepithelial neoplasia in a murine tumor induction model
High-dose dietary zinc promotes prostate intraepithelial neoplasia in a murine tumor induction model
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DOI：
10.1038/aja.2009.74
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发表时间：
2010-03-01
影响因子：
2.9
通讯作者：
Cheon, Jun
中科院分区：
文献类型：
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作者：
Ko, Young Hwii;Woo, Yu Jeong;Cheon, Jun
为了研究高剂量膳食锌在前列腺恶性肿瘤发生过程中的作用，将60只sd大鼠随机分为4组：有致癌物和激素诱导肿瘤组（1组）、无诱导肿瘤的口服锌组（2组）、有诱导肿瘤的口服锌组（3组）和无诱导和无锌的对照组（4组）。第2组和第3组以七水合硫酸锌溶于饮用水的形式口服锌，连续20周。虽然各组血清锌含量在20周时保持相似（P = 0.082），但前列腺内锌浓度有统计学差异。1组前列腺背外侧和腹侧叶锌含量最低，分别为36.3和4.8 μ g / g（-1）。然而，在第3组，锌含量分别增加到59.3和12.1 μ g g(-1)，与第4组（54.5 +/- 14.6和14.1 +/- 2.4 μ g g(-1)）相当。尽管锌浓度增加，但前列腺上皮内肿瘤的患病率在3组（53.3%和46.7%）比1组（33.3%和33.3%）在前列腺叶背外侧和腹侧都增加了。虽然在第4组中没有前列腺上皮内肿瘤的发生，但在第2组中，锌确实诱导了前列腺上皮内肿瘤的发生（46.7%和40.0%）。因此，尽管高锌饮食增加了前列腺内锌浓度，但在小鼠前列腺恶性肿瘤诱导模型中，它促进而不是预防前列腺上皮内肿瘤。
To evaluate the role of high-dose dietary zinc in the process of prostate malignancy, 60 Sprague-Dawley rats were randomly divided into four groups: tumor induction with carcinogen and hormone (group 1), oral zinc administration without tumor induction (group 2), oral zinc administration with tumor induction (group 3) and a control without zinc administration or tumor induction (group 4). Zinc was supplied orally in the form of zinc sulfate heptahydrate dissolved in drinking water to groups 2 and 3 for 20 weeks. Although the serum level of zinc measured at 20 weeks was maintained similarly in each group (P = 0.082), intraprostatic zinc concentrations were statistically different. Group 1 prostates contained the least amount of zinc in both the dorsolateral and ventral lobes at levels of 36.3 and 4.8 mu g g(-1), respectively. However, in group 3, zinc levels increased in both lobes to 59.3 and 12.1 mu g g(-1), respectively, comparable with that of group 4 (54.5 +/- 14.6 and 14.1 +/- 2.4 mu g g(-1)). In spite of these increases in zinc concentration, the prevalence of prostate intraepithelial neoplasm was rather increased in group 3 (53.3% and 46.7%) compared with group 1 (33.3% and 33.3%) in both dorsolateral and ventral prostate lobes. Although prostate intraepithelial neoplasm did not develop in any prostate in group 4, zinc administration did induce prostate intraepithelial neoplasm in group 2 (46.7% and 40.0%). Thus, although high dietary zinc increased intraprostatic zinc concentrations, it promoted, instead of preventing, prostate intraepithelial neoplasm in a murine prostate malignancy induction model.