CHANGE TOWARDS EARLIER STAGE AT PRESENTATION OF COLORECTAL-CANCER
CHANGE TOWARDS EARLIER STAGE AT PRESENTATION OF COLORECTAL-CANCER
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DOI：
10.1002/bjs.1800801241
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发表时间：
1993-12-01
影响因子：
9.6
通讯作者：
MANGHAM, CM
中科院分区：
文献类型：
--
作者：
ROBINSON, MHE;THOMAS, WM;MANGHAM, CM
对10年来结直肠癌患者的临床分期变化进行了研究。病例是从参加基于大肠隐匿性肿瘤筛查的随机对照研究的受试者的对照组中确定的。在对照组的405名受试者(表现为有症状的结直肠癌)中，206人在1989年之前有症状，199人在1989年之后出现。1989年以来确诊的DUKES‘A期癌症患者数量从21例(10.4%)增加到35例(18.1%)；这种变化发生在直肠乙状结肠癌(1989年之前为9.9%，1989年之后为28%，但结肠癌除外)(1989年之前为10.9%，之后为11.5%)。在过去的10年里，观察到有症状的早期直肠乙状结肠癌患者的比例有所增加。在结肠癌患者中没有发生这样的变化。这可能反映了患者和全科医生对该病及其症状的认识发生了变化。
A study was carried out to investigate the change in stage at presentation of patients with colorectal cancer over 10 years. Cases were identified from the control group of subjects enrolled into a randomized controlled study based on Haemoccult screening for colorectal neoplasia. Of 405 subjects in the control group (presenting with symptomatic colorectal cancer, 206 presented before 1989 and 199 since then. The number of patients with Dukes' stage A carcinoma diagnosed since 1989 rose from 21 (10.4 per cent) to 35 (18.1 per cent); this change occurred for rectosigmoid tumours (9.9 per cent before 1989, 28 per cent after 1989 but not for colonic cancer (10.9 per cent before 1989, 11.5 per cent thereafter). An increase in the proportion of patients with symptomatic early-stage rectosigmoid cancer has been observed in the past 10 years. No such change occurred in those with colonic cancer. This may reflect a change in awareness of the disease and its symptoms by patients and general practitioners.